Article Dans Une Revue Nuclear Receptor Signaling Année : 2008

Regulatory function of the P295-T311 motif of the estrogen receptor alpha - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses?

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The way in which estrogen receptor α (ERα) mediates gene transcription and hormone-dependent cancer cell proliferation is now being largely reconsidered in view of several recent discoveries. ERα-mediated transcription appears to be a cyclic and transient process where the proteasome - and thus receptor degradation - plays a pivotal role. In view of our recent investigations, which demonstrate the estrogenic activity of a synthetic peptide corresponding to a regulatory motif of the receptor (ERα17p), we propose that ERα proteasomal degradation could induce the emergence of regulatory peptide(s). The latter would function as a signal and contribute to the ERα activation process, amplifying the initial hormonal stimulation and giving rise to sustained estrogenic response.
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hal-00348100 , version 1 (21-01-2025)

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Dominique Gallo, Iman Haddad, Guy Laurent, Joëlle Vinh, Françoise Jacquemotte, et al.. Regulatory function of the P295-T311 motif of the estrogen receptor alpha - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses?. Nuclear Receptor Signaling, 2008, 6, pp.e007. ⟨10.1621/nrs.06007⟩. ⟨hal-00348100⟩
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