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Article Dans Une Revue Journal of Alzheimer's Disease Année : 2024

Mapping cognitive trajectories and detecting early dementia using the MMSE Cognitive Charts: application to the French Three-City Cohort

Résumé

The Cognitive Quotient (QuoCo) classification algorithm monitoring decline on age- and education-adjusted Mini-Mental State Examination (MMSE)-derived cognitive charts has proved superior to the conventionally-used cut-off for identifying incident dementia; however, it remains to be tested in different settings. Data were drawn from the Three-City Cohort to 1) assess the screening accuracy of the QuoCo, and 2) compare its performance to that of serial MMSE tests applying different cut-offs. For the QuoCo, sensitivity was 74.2 (95% CI: 71.4–76.8) and specificity 84.1 (83.6–84.7) and for the MMSE < 24, 64.1 (61.1–67.0) and 94.8 (94.4–95.1), respectively; whereas overall accuracy and sensitivity was highest for MMSE cut-offs <25 and <26. User-friendly charts for mapping cognitive trajectories over visits with an alert for potentially ‘abnormal’ decline can be of practical use and encourage regular monitoring in primary care where the <24 cut-off is still widely used despite its poor sensitivity.
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Dates et versions

hal-04590046 , version 1 (28-05-2024)

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Joanna Norton, Laure-Anne Gutierrez, Christian Gourdeau, Hélène Amieva, Patrick Bernier, et al.. Mapping cognitive trajectories and detecting early dementia using the MMSE Cognitive Charts: application to the French Three-City Cohort. Journal of Alzheimer's Disease, 2024, 98 (2), pp.403-409. ⟨10.3233/JAD-231176⟩. ⟨hal-04590046⟩
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